Background Epidemiological evidence suggests a strong association between osteoporosis (OP) and nephrolithiasis (NL), yet the causal direction of this relationship remains debated. This study aimed to elucidate the bidirectional causal relationship between OP and NL using a two-sample Mendelian randomization (MR) appro...
Gwo-Tsann Chuang, Chia-Ni Hsiung, Tony Pan-Hou Che et al.· American Journal of Nephrolo...· 0 citations
Background
Chronic kidney disease (CKD) is a major global public health issue, with genetic factors playing a significant role in kidney function. Although genome-wide association studies (GWAS) have identified numerous loci associated with estimated glomerular filtration rate (eGFR), most studies relied on a single ti...
Yi-Chih Lin, Hsiao-Mei Tsao, Jacob Shu-Jui Hsu et al.· Kidney Research and Clinical...· 0 citations
This work fine-mapped UK Biobank-derived genome-wide association study (GWAS) signals from 164 traits and identified e/sQTL colocalizations for 10,611 GWAS signals, including 7096 that colocalize with secondary e/sQTLs.
Peter Orchard, T. Blackwell, L. Kachuri et al.· Science· 0 citations
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