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Yichong Lao

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Open access Aug 2026

Progressive Loosening of a Dual Autoinhibitory Interface Activates PP2A-B56δ

Protein phosphatase 2A containing the B56δ regulatory subunit (PP2A-B56δ) is a critical signaling enzyme whose dysregulation is associated with cancer, neurodegenerative disorders, and Jordan’s syndrome, a severe intellectual disability disorder caused by mutations in B56δ. Unlike other PP2A holoenzymes, PP2A-B56δ is r...

Michael S O'Connor, Cheng-Guo Wu, Yi-Chong Lao et al. · 0 citations

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