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Open access Oct 2026

Trigonelline Alleviates Neuroinflammation in AAV‐SynA53T Parkinson's Disease Model Mice: Involvement of PI3K/AKT–NF‐κB Signaling and Gut Microbial‐Metabolic Remodeling

ABSTRACT Trigonelline (TG), a major alkaloid in fenugreek seed and coffee, has anti‐inflammatory and antioxidant activities. We investigated whether TG ameliorates Parkinson's disease (PD)‐related synucleinopathy and whether these effects are associated with inflammatory signaling and gut microbial–metabolic alteration...

Mo-Zi Chen, Yi Dong, Jie Zheng et al. · 0 citations

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