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Yi-Fan Chen

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Oct 2026

Metabolomic aging and mortality clocks based on ensemble learning identify systemic aging risk across the human life span in 18,476 individuals.

Aging is characterized by progressive functional decline, yet metabolomic signatures across the human life span remain incompletely defined. Here, we profiled plasma metabolomes from 18,476 participants aged 1 to 96 years across six centers in China using nano-assisted laser desorption/ionization mass spectrometry (LDI...

Lin-Lin Cao, Yi-Fan Chen, Wei Zhang et al. · 0 citations
Open access Oct 2026

Precision medicine for resistant hypertension: integrating molecular phenotyping, gut microbiome, device therapy and digital care

Abstract Resistant hypertension confers substantial cardiovascular and renal risk. However, apparent treatment resistance often arises from reversible problems rather than a discrete biological disease. Precision management starts with confirming true resistant hypertension through standardized office measurement, out-...

Yan Tang, Jia-Yi Yao, Yi-Fan Chen et al. · 0 citations

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