Dual-responsive liposomal nanoplatform integrating MMP-2 inhibition and EV-enhanced intratumoral delivery for synergistic anti-tumor and anti-metastatic therapy.
Inhibiting the activity of matrix metalloproteinases (MMPs) to preserve extracellular matrix (ECM) integrity and impede metastasis remains challenging with conventional chemotherapeutics. To address this, we developed liposomal nanoparticles (Lip/Dox/Mon-Pep NPs) for the inhibition of both tumor growth and metastasis....