Author

Yi-Fan Liu

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Open access Sep 2026

Integrated Multi-Omics and Experimental Evidence Implicates PDCD5 as a Candidate Gene Associated with Primary Biliary Cholangitis

Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disorder in which endoplasmic reticulum stress and mitochondrial dysfunction overlap with features associated with paraptosis. This study aimed to identify a paraptosis-related candidate gene for PBC via multi-omics integration and experimental valida...

Zi-Hao Xu, Yi-Fan Liu, Cong-Cong Cao et al. · Life · 0 citations

Open access Sep 2026

Pasteurized Akkermansia muciniphila as a candidate multi-effector pharmacological system in the gut-liver axis: evidence, unresolved causality, and translational priorities

Pasteurized Akkermansia muciniphila is a clinically tractable postbiotic candidate, but its activity cannot be assigned to a single principle. Heat-stable Amuc_1100 is demonstrably retained in pasteurized cells, whereas the GLP-1-inducing protein P9, extracellular vesicles (AmEVs), membrane lipids, and diffusible m...

Yi-Fan Liu, Zi-Hao Xu, Dong-Seon Kim et al. · Frontiers in Pharmacology · 0 citations

Open access Sep 2026

PTEN-L inhibits mitophagy and GSDME-dependent pyroptosis via Parkin dephosphorylation.

Mitochondrial dysfunction is a potent trigger of inflammatory cell death; however, the precise signaling pathways linking mitochondrial damage to pyroptosis remain incompletely understood. Here, we identify a previously unrecognized pathway in which mitochondrial depolarization activates the PINK1-Parkin axis to drive...

Cheng-Hao Yan, Cai-Nian Huang, Xu Liu et al. · EMBO Reports · 0 citations