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Author

Yi-Fan Zhang

2 papers indexed here

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Open access Oct 2026

Oncolytic adenovirus-mediated delivery of anti-CLDN18.2 IgG3 for the treatment of solid tumors

Abstract Background Claudin 18.2 (CLDN18.2) is a promising therapeutic target for gastric, pancreatic and ovarian cancers. The Food and Drug Administration-approved antibody, zolbetuximab (IgG1), induces tumor cell death via antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis...

Lei Pei, Wan-Rong Zhang, Hao-Ran Zhu et al. · 0 citations
Review Oct 2026

Reprogramming the Myeloid-T Cell Ecosystem through Engineered Oncolytic Viruses for Durable Antitumor Immunity.

Oncolytic virotherapy (OVT) has emerged as a promising immunotherapeutic strategy that combines selective tumor destruction with systemic immune activation. However, durable clinical responses remain limited because current approaches largely focus on viral replication and oncolysis while overlooking the immune network...

Chuan-Jian Wu, Wang-Lu Gu, An-Dong Qin et al. · 0 citations

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