Yi-Fang Yang

Chemical Control Methods for Intramolecular Ring-Closing Selectivity in Peptide Macrocyclization

Peptide macrocyclization is a pivotal strategy in the development of bioactive cyclic peptides, yet achieving precise intramolecular ring-closing selectivity remains a formidable synthetic challenge. Multiple competing reaction pathways, including undesired intermolecular oligomerization, self-cyclization at alternativ...