Open access
Sep 2026
PRKX-mediated stabilization of PD-L1 characterizes an immunosuppressive gastric cancer subtype
PRKX drives immune exhaustion in the GC1 subtype by stabilizing PD-L1 through phosphorylation-dependent inhibition of ubiquitination, thereby promoting immune evasion and targeting PRKX represents a potential strategy to overcome resistance to anti-PD-1 therapy.
Qi-Yue Wang, Yin-Qi Chen, Dong-Dong Huang et al.
· Journal for ImmunoTherapy of... · 0 citations