Author

Yi-Han Lin

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Open access Oct 2026

Virtual lineages: in silico lineage tracing from single-cell and spatial transcriptomes

Experimental lineage tracing reveals histories and fates of individual cells but is costly and often impractical, particularly in primary human tissues. Gene expression differences that persist across cell divisions provide a basis for inferring ancestry from more accessible single cell transcriptomes, yet accurate lin...

Yong-Jie Lin, Yi-Han Lin · bioRxiv · 0 citations

Open access Aug 2026

Structure-aware deep learning enhances m6A prediction and reveals cell type-associated RNA structural signatures

It is demonstrated that sequence and structure provide complementary predictive information, and that sites with greater prediction sensitivity to structural perturbation exhibit distinct local structural profiles between cell lines, and provides a multifeature deep learning framework for accurate and interpretable str...

Ming-Ze Sun, Di Zhang, Zhi-Yuan Li et al. · PLoS Computational Biology · 0 citations