Author

Yi-Hsien Hsieh

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Open access Oct 2026

Disruption of p-AKT/ERβ-Mediated Midkine Signaling Promotes the Antimetastatic Effects of Timosaponin AIII in Nasopharyngeal Carcinoma Cells

Background: Nasopharyngeal carcinoma (NPC) is a highly metastatic epithelial malignancy with limited therapeutic options for advanced disease. Timosaponin AIII (TSAIII), a natural steroidal saponin, exhibits antitumor activity; however, its effects on NPC progression and the molecular mechanisms remain unclear. Method:...

Chu-Che Lee, Yong-Syuan Chen, Shun-Fa Yang et al. · Cells · 0 citations

Open access Aug 2026

Tricin Inhibits Human Osteosarcoma Cell Metastasis via Suppression of ZNF503 and the PI3K–PIP3–Akt Pathway

Osteosarcoma is the most common primary malignant bone tumor and is associated with a high mortality rate due to its pronounced metastatic potential. Although tricin has been proposed as a chemosensitizer in various malignancies, its anti‐metastatic effect in osteosarcoma remains poorly characterized. This study invest...

Chia-Hsuan Chou, Jia-Sin Yang, Pei-Ni Chen et al. · Drug development research (P... · 0 citations

Open access Aug 2026

ESM1-mediated DNMT3A suppresses cervical cancer metastasis through epigenetic regulation of ID3 expression

In vivo xenograft and experimental metastasis models validated that ESM1 depletion significantly impaired tumor growth and lung metastasis while increasing ID3 expression, identifying the ESM1/DNMT3A/ID3 axis as a novel epigenetic driver of cervical cancer and a potential therapeutic target.

Chen-Lin Yu, Chia-Liang Lin, Hsiang-Lin Lee et al. · Cell Death Discovery · 0 citations