Biomimetic hybrid nanoparticles from grape-derived exosome-like particles and liposomes potentiate JQ1-mediated anti-fibrotic effects in hepatic stellate cells.
Activated hepatic stellate cells (HSCs) play a central role in liver fibrosis by promoting extracellular matrix deposition, oxidative stress, and pro-fibrotic signaling. Here, we engineered a membrane-fused hybrid nanoparticle by combining grape-derived exosome-like particles (GELPs) with liposomes to encapsulate JQ1,...