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Yi-Jiang Li

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Review Open access Aug 2026

In Vivo Base Editing for Neonatal Inborn Errors of Metabolism: Clinical Progress, N-of-1 Therapy, and the Ethics of Bespoke Genetic Medicine

This review synthesizes the clinical rationale for genetic correction of neonatal IEMs, the mechanistic basis and delivery strategies that make in vivo base editing feasible, and the preclinical evidence that preceded the first human case and examines the ethical dimensions of bespoke 'N-of-1' genetic medicine.

O. Li, Yi-Jiang Li, Su-Jing Li · 0 citations

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