Xanthine Oxidase Inhibitory Peptides from Sesame 11S Globulin Target the FAD Domain: Kinetics, Molecular Dynamics, and Validation in a Zebrafish Hyperuricemia Model.
Food-derived bioactive peptides are promising alternatives to conventional xanthine oxidase (XO) inhibitors, yet individual XO inhibitory peptides from sesame protein remain uncharacterized. Here, sesame and peanut protein isolates were screened with four proteases; the trypsin hydrolyzate of sesame (TSH, 120 min) show...