Yi-Jue Wu

Dominant doubly charged ion enabling robust LC-MS/MS quantification of a novel small-molecule antibacterial drug Cefidelbaz in human plasma and its application to pharmacokinetic and protein binding studies.

Cefidelbaz is a novel siderophore cephalosporin antibacterial agent with a unique "Trojan horse" mechanism, which can combat some of the most difficult-to-treat Gram-negative bacterial infections. In mass spectrometric analysis, cefidelbaz generated distinct precursor ions in both positive and negative modes during the...