Copper-Catalyzed Enantioselective Vinylogous Hydroxylation with Nitrosobenzene.
Catalytic asymmetric vinylogous hydroxylation remains a largely uncharted transformation. This limitation mainly arises from two inherent obstacles: selectivity issues (regio- and enantioselectivities) and the oxidative reactivity of common oxygen donors, both of which severely compromise overall catalytic efficiency....