Author

Yi Long

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Open access Oct 2026

GaussF: An Unbiased Gaussian Framework for High-Precision Transcript Quantification with a Programmable Self-Benchmark Model

Short-read RNA sequencing has revolutionized transcriptome analysis, but accurate isoform-level quantification faces substantial challenges from overlapping sequences among complex isoforms and inherent sequencing biases, leading to uneven coverage. Current alignment-based and alignment-free methods, while valuable, la...

Qiang Su, Yi Long, De-Ming Gou et al. · bioRxiv · 0 citations

Aug 2026

Pattern-Filter structural validation of single-cell RNA-seq reads reduces artifactual barcodes and improves biological resolution.

These findings establish structural validation as an essential prerequisite for analysis, positioning Pattern-Filter as a useful standard for ensuring molecular fidelity and reliable biological discovery in single-cell transcriptomics.

Qiang Su, Xiao-Ming Zhou, Yi Long et al. · Genome Research · 0 citations

Open access Jul 2026

scReGAT: Leveraging Knowledge of Regulatory Interactions to Predict Long-range Gene Regulation at Single-cell Resolution.

By integrating genome-wide association studies loci from Alzheimer's disease, multiple sclerosis, and schizophrenia, scReGAT identifies disease-associated cell types and uncovers candidate regulatory mechanisms underlying complex trait associations, positioning scReGAT as a robust and generalizable framework for decodi...

Baole Wen, Yanan Dang, Yu Zhang et al. · Genomics, Proteomics & Bioin... · 0 citations