Journal Pre-proof Bi-directional epithelial-mesenchymal crosstalk provides self-sustaining pro-fibrotic signals in pulmonary fibrosis
Liu-Di Yao, Yi-Lu Zhou, Juan-Juan Li et al.
· 0 citations
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Open access
Sep 2026
A canonical role of SMAD4 in safeguarding 3D genome architecture to suppress lung tumorigenesis.
Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcription factor activity by directly binding c...
Ya-Ping Xu, Xin-Yan Han, Jun-Ming Li et al.
· Oncogene · 0 citations