Author

Yi Luo

2 papers indexed here

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Sep 2026

LASS2 alleviates liver fibrosis by interacting with THBS1, TFRC, and APOE to inhibit TGF-β1 signaling and ferroptosis, and by reshaping the hepatocyte lipid secretome to suppress paracrine HSC activation.

BACKGROUND Liver fibrosis (LF) lacks effective therapies. Longevity assurance homolog 2 (LASS2), a key ceramide synthase, contributes to liver homeostasis, but its role in LF remain unclear. METHODS Bioinformatics revealed LASS2 correlation with classic fibrotic factors, and its expression was assessed in fibrotic mo...

Rong-Jin Yu, Xiao-Yu Li, Yun-Fei Huang et al. · Cellular Signalling · 0 citations

Open access Sep 2026

Nasal exposure to PM2.5 induces testicular injury and activation of pyroptosis-related signaling in rats: Inhibitor intervention and public transcriptomic analysis

Objective This study aimed to investigate the testicular injury induced by PM2.5 and the associated enhancement of NLRP3/caspase-1/GSDMD-related pyroptotic signaling in rats by integrating animal experiments with public transcriptomic analysis. Methods Thirty-two male Sprague-Dawley rats were randomly assigned to four...

Yi Luo, Cao Wang, Meng-Xi Tian et al. · PLoS ONE · 0 citations