Yi-Miao Zhu

Accurate Identification of Covalently Ligandable Cysteines Using CCSite.

Targeted covalent inhibition is an important strategy in modern drug discovery, with cysteine being the most common residue targeted for covalent ligands. Accurate identification of covalently ligandable cysteines is therefore essential, especially for traditionally "undruggable" targets. However, structure-based metho...