Review
Open access
Aug 2026
Spatially-resolved pharmaco-ecology of immunotherapy resistance in lung adenocarcinoma: Single-cell and spatial transcriptomics for mechanism-matched combination therapies
Future clinical translation requires protein validation, functional perturbation, multi-region sampling, and prospective trials to convert spatial ecological insights into mechanism-matched combination therapies, according to single-cell and spatial transcriptomics.
Yi-Ming Hua, Zhan-Yang Luo, Zhi-Mei Huang
· Translational Oncology · 0 citations