Open access
Sep 2026
CXXC1-dependent IRF4 activity promotes myeloma cell fitness and sustains lenalidomide resistance.
Regulation of oncogenic transcriptional programs in multiple myeloma requires the interplay of histone modifications, their writers and readers with lineage-affiliated transcription factors. The transcription factors IKZF1/3, IRF4 and MYC form an aberrant, myeloma-specific regulatory loop that drives myelomagenesis and...
P. Sabbattini, Nikolaos Trasanidis, J. Taslim et al.
· Blood · 0 citations