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Author

Yi-Quan Chen

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Open access Sep 2026

Cornea-Penetrating Nanodrug Co-Delivering VEGF-Silencing siRNA and Lutein for Treating Age-Related Macular Degeneration.

A noninvasive, cornea-penetrating nanodrug based on chitosan-modified lipid-polymer hybrid nanoparticles (LPNPs) for co-delivery of lutein and VEGF-silencing siRNA (Chi@Lu/si NPs) to treat AMD, which interrupts the pathological cycle driving CNV progression.

Yong Li, Fan Xiao, Zi-Wei Liu et al. · 0 citations
Open access Aug 2026

ACE2-PNA conjugates exploit viral endocytosis for targeted intracellular delivery and exhibit dual antiviral efficacy against SARS-CoV-2

A Receptor-Drug Conjugate (RDC) strategy, in which a therapeutic payload is covalently linked to a decoy receptor, enabling virus-triggered targeted intracellular delivery, and has significant implications for reducing off-target toxicity and enhancing antiviral potency.

Yi-Fei Wang, Jing-Han Xu, Yi-Quan Chen et al. · 0 citations

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