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Yi-Qun Wang

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Review Open access Sep 2026

The microbiome–inflammasome axis in endometriosis-associated chronic pelvic pain: mechanisms and therapeutic opportunities from an immunological perspective

Convergent preclinical and observational evidence suggests that dysbiosis of the gut and reproductive tract microbiota may activate TLR4 via lipopolysaccharide, triggering NF-κB signaling and promoting NLRP3 inflammasome priming and activation, which may contribute to M1-skewed pelvic inflammation, adaptive immune alte...

Xia Ma, Kang Lin, Yi-Qun Wang et al. · 0 citations
Aug 2026

Machine learning-integrated molecular subtyping reveals two biologically distinct endometriosis subtypes in the EndometDB database.

BACKGROUND Endometriosis affects approximately 10% of reproductive-age women, with a diagnostic delay of 7-10 years. Despite clinical heterogeneity, current rASRM staging poorly predicts treatment outcomes. Molecular subtyping may reveal biologically meaningful patient strata that complement anatomical staging. OBJEC...

Yi-Qun Wang, Xiao-Xiao Cai, Yi Xu et al. · 0 citations

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