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Author

Yi-Qun Xie

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Open access Aug 2026

Subtype-Dependent Transcriptional Coupling Between DNMT1 and E2F-Linked Proliferative Programs in Breast Cancer: A Dual-Cohort Transcriptomic Analysis

Background DNMT1 is a maintenance DNA methyltransferase involved in replication-coupled epigenetic regulation and is frequently expressed in highly proliferative tumors. Although DNMT1 has been linked to RB-E2F-related transcriptional programs, the reproducibility and subtype dependence of this association in breast ca...

Ping Xiao, Yi-Qun Xie, Rui-Jie Niu et al. · 0 citations

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