Multi-site metabolomics reveals one-carbon and placental steroid disruption in maternal pre-pregnancy obesity linked to adverse pregnancy outcomes
This study characterized metabolomic profiles of maternal adipose tissue, placenta, and cord blood in pre-pregnancy obesity and explored links to adverse pregnancy outcomes (APOs). From a prospective cohort (Oct 2024–Oct 2025, n = 1,335), 25 obese (pre-pregnancy BMI ≥ 28 kg/m 2 ) and 25 control women...