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Yi-Shu Zhang

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#artificial intelligence Preprint Sep 2026

Multimodal LLMs Outperform Pathology Foundation Models in Cross-Domain Histological Similarity

State-of-the-art pathology foundation models, trained on millions of histology tiles, can fail to preserve tissue similarity when comparisons cross slide or institution boundaries. We show that general-purpose multimodal LLMs, without being trained as pathology foundation models, consistently outperform these specializ...

Yi-Shu Zhang, Yun Li, Dai-Wei Zhang · 0 citations

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