Yi-Ting Wang

TIGRa: An ultra-compact programmable activator enabling multiplexed and efficient gene regulation

SUMMARY Programmable gene activation has broad therapeutic potential but remains constrained by large effector size, limited multiplexing capacity, and challenges in in vivo delivery. Here, we develop TIGRa, a compact transcriptional activator derived from the TIGR-TasR system that is mechanistically distinct from CRIS...