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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yi-Tong Zhao

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Open access Jul 2026

NAD+ metabolic collapse and arrest of epithelial development in Hirschsprung disease

HSCR epithelium displays metabolic fragility characterized by NAD+ biosynthetic insufficiency, increased NAD+ consumption, mitochondrial remodeling, DNA damage, and impaired epithelial maturation, and NAD+-related pathways may represent modifiable programs relevant to postoperative mucosal resilience and susceptibility...

Yi-Tong Zhao, Jielin Yang, Bo Li et al. · 0 citations

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