Open access
Sep 2026
OSU-03012 mitigates pulmonary fibrosis by targeting ECM proteins via suppression of S6K-mediated translation and acceleration of MMP-driven clearance.
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease. Currently available anti-fibrotic therapies are limited to slowing lung function decline; however, inducing the resolution of fibrotic lesions remains highly challenging. This study investigated the anti-fibrotic potential and underlying molecular mec...
Kohei Hashimoto, Masaki Arioka, Toshiki Morimoto et al.
· Biomedicine & pharmacotherap... · 0 citations