Open access
Aug 2026
Repositioning of polyubiquitin alters the pathologic tau filament structure.
It is found that polyubiquitinated tau filaments from Alzheimer disease and vacuolar tauopathy human brain tissue exhibit distinct seeding patterns in mice, in association with differences in tau filament ultrastructure determined by cryo-electron microscopy.
Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich et al.
· Nature Structural & Molecula... · 0 citations