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Author

Yi-Xin Zhang

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Open access Oct 2026

The CX3CL1-CX3CR1 axis in mesenchymal stem cell regulation and bone diseases

The chemokine axis CX3CL1-CX3CR1 is involved in the whole process of bone remodeling, bone injury repair, and inflammation-mediated bone destruction, making it both a diagnostic marker and a potential target for therapy. This article focuses on bone marrow mesenchymal stem cells (BMSCs) to explain the bidirectional mec...

Z. Kuang, Yi-Xin Zhang, Jiao Li · 0 citations
Review Open access Sep 2026

Chronic low-grade inflammation drives skeletal aging and neurocognitive decline: inflammaging as a central hub coupling bone–brain aging

Background Global population aging has driven a marked rise in the co-prevalence of osteoporosis and cognitive impairment, and a bidirectional epidemiological association between the two conditions is now supported by multiple meta-analyses. The shared biological mechanisms underlying this comorbidity, however, remain...

Man Yu, Yu Wu, Ao Wang et al. · 0 citations

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