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Author

Yi Xu

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Aug 2026

Kinetic Resolution of Citronellol by an Engineered Alcohol Oxidase for the Production of (R)-Citronellal and (S)-Citronellol.

(R)-citronellal is an important intermediate for aroma compounds and pharmaceuticals. Herein, we engineered the choline oxidase, AcCO6, from Arthrobacter chlorophenolicus, to enhance enantioselective oxidation of citronellol. Through site-directed and combinatorial mutagenesis, a quadruple mutant, AcCO6_M4a (W332V/A89S...

Peng-Cen Han, Die Lu, Xiao-Mei Wu et al. · 0 citations
Open access Jul 2026

Computational Redesign of Aspartase from Escherichia coli and Its Catalytic Synthesis of β-Alanine

Aspartase from Escherichia coli (AspA) catalyzes the direct conversion of acrylic acid to β-alanine; however, its substrate specificity and low catalytic efficiency limit its broader application. We engineered an AspA mutant capable of efficiently catalyzing the amination of acrylic acid for β-alanine synthesis, using...

Long-Xian Li, Bao-Di Ma, Yi Xu · 0 citations

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