Author

Yi Yan

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Open access Aug 2026

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

The core pathogenic role of the LCN2‐MMP9‐ECM‐FAK axis in GC‐induced muscle atrophy is revealed, providing a promising novel therapeutic target for steroid myopathy.

Hongwei Shi, Xiaojing Hao, Yi Yan et al. · Advancement of science · 0 citations

Jul 2026

TOPS-CRISPR: Thermally-regulated and oligonucleotide-mediated one-pot CRISPR-Cas12a assay for ultra-sensitive and rapid on-site diagnostics.

A Thermally regulated, Oligonucleotide-mediated one-Pot System for CRISPR-Cas12a (TOPS-CRISPR), which employs a programmable inhibition strategy based on complementary RNA blockers with tunable length and binding sites, enabling efficient and reversible steric inhibition of the LbCas12a-crRNA ribonucleoprotein (RNP) co...

Shusen Ji, Bin Wang, Yi Yan et al. · Biosensors & bioelectronics · 0 citations