Yi-Yang Ding

Inflammation as a central driver in AML pathogenesis and therapy resistance.

Distinct cellular dynamics following CD19 and CD7 CAR-T therapies revealed by high-dimensional CyTOF analysis and impact on clinical outcomes

Compared with CD19 CAR-T therapy, CD7 CAR-T therapy was characterized by reduced CD8+ CAR-T persistence, early exhaustion, and delayed immune reconstitution, correlating with increased infections and higher non-relapse mortality.

NK3 subsets are linked to NK cell exhaustion and immunotherapy responsiveness in tumor.

Natural killer (NK) cells constitute the first line of human immune defense. They have attracted extensive research in the field of tumor immunity owing to their potent cytotoxicity, robust cytokine secretion, and immunomodulatory capacity. However, chronic tumor antigen exposure would induce exhaustion in NK cells (NK...