Yi-Yang Wen

Tight junction suppression by candidalysin promotes gut-to-blood dissemination of Candida albicans

The commensal fungus Candida albicans , a natural inhabitant of the human gut, can transition to a pathogenic state and disseminate into the blood. Disruption of the intestinal mucosal barrier, particularly through the impairment of epithelial cell integrity and intercellular junctions, is a critical step in th...