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Yi-Yi Chen

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Sep 2026

Rational design of heptaprenyl diphosphate synthase and metabolic optimization drive biosynthesis of menaquinone-7 by Escherichia coli.

Menaquinone-7 (MK-7) is a fat-soluble vitamin with important nutritional and pharmaceutical applications. However, microbial biosynthesis of MK-7 is limited by low catalytic efficiency of key enzymes, insufficient precursor supply, and imbalanced availability of nicotinamide adenine dinucleotide phosphate (NADPH). In t...

Zi-Hao Li, Kang-Jie Xu, Yi-Yi Chen et al. · 0 citations

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