During mouse embryogenesis, three sequential waves of cell polarization occur in the 8-cell-morula trophectoderm (TE), E3.5-E4.5 primitive endoderm (PrE), and E4.5-E5.5 epiblast (Epi), driving cell fate determination and morphogenic events that lay the foundation for embryonic development. However, it is not clear whet...
Qian-Ying Yang, Shan Jiang, Bo-Yan Wang et al.· bioRxiv· 0 citations
This work profiled the spatial translatome of intact mouse embryos at near-genomic scale by adapting RIBOmap and incorporating multiplexed organelle staining and found that functionally related genes exhibit spatially and temporally controlled translation patterns near distinct organelles.
Ch chromatin polyvalency model is established as a multi-layered, hierarchical repression mechanism that governs temporal control of gene expression during embryogenesis and disrupts temporal control of polyvalent gene activation.
Starkly, systemic IL-4 treatment rejuvenated the aged hematopoietic system, restoring B and T cell output to youthful levels and mitigating the systemic functional decline associated with inflammaging.
Jingfei Yao, Yuting Wang, Yi Zhang· Journal of Immunology· 0 citations
This work provides a mechanistic link between high-penetrance SETD1A variants and region-specific brain dysfunction, establishing a framework for connecting rare loss-of-function variation in chromatin regulators to multidimensional neuropsychiatric phenotypes.
