Author

Yi-Zhong Bao

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Open access Aug 2026

KDM6A suppresses proliferation and epithelial-mesenchymal transition in prostate cancer cells.

BACKGROUND AND OBJECTIVE Prostate cancer is one of the most common male malignancies worldwide. KDM6A, a histone H3K27 demethylase, has been implicated in various cancers; however, its specific functions in prostate cancer remain controversial. This study aimed to investigate the regulatory role of KDM6A in castration-...

Yi-Xiu Ni, Yi-Jia Lin, Wan-Kun Wang et al. · Urologic oncology · 0 citations

Open access Sep 2026

Follistatin drives AR-independent prostate cancer through BMP signaling inactivation and microenvironmental remodeling.

Resistance to androgen receptor (AR)-targeted therapies remains a major clinical challenge in advanced prostate cancer. Here we identify follistatin (FST), TGFβ superfamily antagonist, as a key driver of AR-independence and treatment resistance. During anti-AR therapy, cancer cells progressively lose the positive feedb...

Xiao-Xian Shi, Zu-Yan Fan, Min Qu et al. · Proceedings of the National... · 0 citations