Author

Yi Zhou

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Open access Sep 2026

VGLL4 enhances PDK4 transcription and promotes metabolic dysfunction-associated fatty liver disease.

MAFLD is a global epidemic with a limited number of approved targeted therapies, underscoring the urgent need to define its underlying regulatory mechanisms. Here, we identify VGLL4 as a positive regulator of MAFLD progression. Hepatocyte-specific overexpression of Vgll4 induces hepatic steatosis, insulin resistance, a...

Yi-Xing Chen, Xiao-Dong Wang, Wen-Tao Yu et al. · EMBO Reports · 0 citations

Aug 2026

Multimodal brain cell atlas across the adult macaque lifespan.

A comprehensive transcriptomic and chromatin accessibility atlas of 8 brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links t...

Xiao Zhang, Guang-Shun Lai, Xiang-Yu Guo et al. · Cell · 0 citations