Role of CircRNA_0005075 in gastric cancer immune evasion through regulation of lactate metabolic reprogramming and histone lactylation.
PURPOSE Gastric cancer remains one of the most lethal malignancies worldwide. While immune checkpoint inhibitors targeting the PD-1/PD-L1 axis have significantly advanced the treatment of advanced gastric cancer, their efficacy exhibits marked heterogeneity among patients, with a substantial proportion showing primary...