Yichong Lao

Progressive Loosening of a Dual Autoinhibitory Interface Activates PP2A-B56δ

Protein phosphatase 2A containing the B56δ regulatory subunit (PP2A-B56δ) is a critical signaling enzyme whose dysregulation is associated with cancer, neurodegenerative disorders, and Jordan’s syndrome, a severe intellectual disability disorder caused by mutations in B56δ. Unlike other PP2A holoenzymes, PP2A-B56δ is r...