Diploid genomes carry millions of heterozygous variants in cis-regulatory DNA, yet most genes produce similar RNA output from two parental alleles. How this balance is maintained is unclear. We developed Nanopore-HiChIP, a long-read method that maps high-order enhancer hubs on each haplotype. Over half of these enhance...
Jiang Tan, M. Sentmanat, Yu-Qing Wu et al.· bioRxiv· 0 citations
Dosage compensation (DC) in Drosophila equalizes X chromosome–linked gene expression via the male-specific lethal complex, which acetylates histone 4 lysine-16 on the male X chromosome. How DC is established during early embryogenesis remains obscure, largely due to the difficulty of obtaining sufficient sex-specific m...
Ronald Oellers, A. Alexiadis, Yidan Sun et al.· Science Advances· 0 citations
NextLongIso is presented, a scalable and reproducible Nextflow pipeline that enables coordinated analysis of multiple layers of transcript regulation and facilitates the transition from transcript identification to functional interpretation of transcriptomic variation.
TrioMix-UPD, an integrated short- and long-read sequencing framework for UPD detection and classification, is developed and established UPD as an underrecognized contributor to CHD.
Nahyun Kong, Javier Abello, Christopher J. Yoon et al.· Research Square· 0 citations
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