Yidong Zhou

Advances in single-cell and spatial multi-omics for deciphering the mechanisms of pan-organ metastasis in breast cancer.

Breast cancer deaths are mainly caused by metastasis to distant organs, not by the primary tumor. Bone, lung, liver, and brain are the most common metastatic sites, each showing different clinical behaviors and treatment responses-a pattern often called metastatic organotropism. Bulk omics can provide tissue-level info...