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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Yifan J. Li

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Open access Jul 2026

Unmasking Supervillin: SVIL haploinsufficiency causes hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics

Background Rare heterozygous loss-of-function (LoF) variants in SVIL, encoding the Z-disk and costameric protein supervillin, have recently been identified as a cause of hypertrophic cardiomyopathy (HCM). Although supervillin is implicated in actin-dependent mechanotransduction, the mechanisms linking SVIL deficiency t...

Yifan J. Li, BMedSci Yiangos Psaras MBChB, V. Steeples et al. · 0 citations
Jul 2026

METTL3‐Activated IDO1‐Kynurenine Pathway in Insulin‐Producing Cells Enhances Graft Survival and Attenuates Endogenous Islet Apoptosis in Diabetic Mice

It is shown that METTL3 overexpression is associated with IDO1 upregulation and elevated systemic Kyn levels, which suggest that the METTL3‐IDO1‐Kyn pathway may be a potential target for improving cell replacement therapy for diabetes.

Shan Xu, Li-Xuan Fang, Jia-Jun Qiu et al. · 0 citations

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