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Open access Aug 2026

Reduced microvascular coverage links a hypoxia-associated niche to microglial autophagic dysfunction in Parkinson’s disease

A “double-hit” model in which hypoxia-associated stress may amplify α-Syn-induced microglial dysfunction through HIF1A-linked metabolic remodeling and impaired autophagy-related protein handling is supported, which supports a “double-hit” model for advanced PD.

Hua-Lin Wang, Zhuang Zhu, Zefu Yin et al. · 0 citations

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