Open access
Aug 2026
Reduced microvascular coverage links a hypoxia-associated niche to microglial autophagic dysfunction in Parkinson’s disease
A “double-hit” model in which hypoxia-associated stress may amplify α-Syn-induced microglial dysfunction through HIF1A-linked metabolic remodeling and impaired autophagy-related protein handling is supported, which supports a “double-hit” model for advanced PD.
Hua-Lin Wang, Zhuang Zhu, Zefu Yin et al.
· Acta Neuropathologica Commun... · 0 citations