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This chapter systematically examines three progressive tiers of PROTAC delivery using stimuli-activatable moieties, and highlights how these strategies achieve spatiotemporally controlled, tumor-selective protein degradation while minimizing off-tumor toxicity.
This Review provides a framework for selecting disease-matched degradation routes and advancing meTPDs from platform-specific demonstrations towards predictable therapeutic modalities by integrating molecular design, receptor biology, intracellular trafficking, delivery and pharmacodynamic considerations.
This Account systematically summarizes recent advances regarding the rational design of stimuli-activatable protein degraders, and strategically outline the "when and how" of integrating these degraders with nanomedicine platforms to tailor precise cancer therapy.
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