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Yijun Gu

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Open access Aug 2026

From probe to prodrug: immunoproteasome activity as a trigger for disease-selective therapeutics

Developing novel strategies that can exploit a cell's endogenous machinery to selectively release toxic compounds in diseased cells, while leaving healthy cells unaffected, is a challenging task to accomplish. An established approach involves antigen recognition on tumor cells, enabling targeted delivery of prodrugs in...

Cody A. Loy, Yijun Gu, Samuel C. Kim et al. · 0 citations
Open access Aug 2026

EvoSNR-Prom: Predicting promoters at single-nucleotide resolution with label-aware transfer learning of the pretrained EVO model

EvoSNR-Prom is built on the Evo foundation model and formulates promoter identification as a token-level sequence labeling problem, analogous to named entity recognition in natural language processing, and a lexicon-enhanced embedding strategy is introduced that incorporates biologically meaningful DNA lexicons, enrich...

Pi-Jing Wei, Wen-Kang Zheng, Yijun Gu et al. · 0 citations

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