Cyclic di-GMP directly reprograms the multidrug resistance machinery via UspG-mediated sequestration of RamR in Klebsiella
This study identifies that upon the elevation of intracellular c-di-GMP levels induced by antibiotic treatmen, the universal stress protein UspG serves as a cryptic, direct c-di-GMP effector in extended-spectrum beta-lactamase (ESBL)-producing strain K. pneumoniae, and indicates that UspG is functionally conserved acro...