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A novel deep learning framework based on Transformer, coined as TransNRank, that streamlines the prediction pipeline but also sets a new state-of-the-art for neoantigen discovery, with broad implications for accurate immuno-oncology.
The findings suggest that mRNab-LNPs offer a promising alternative to current therapies, providing a safer, more efficient approach to treating autoimmune diseases by resetting the humoral immune system.
Renal cell carcinoma (RCC) remains highly resistant to conventional therapies, highlighting the need for innovative treatments. Tumor-associated macrophages (TAMs) play a critical role in RCC progression by promoting immune evasion and supporting tumor growth. Manganese ions have been shown to activate the cGAS-S...
A dual-targeting strategy disrupted the TME-induced immune suppression, reduced collagen deposition, and boosted T cell activity, resulting in notable tumor growth inhibition and prolonged survival in both subcutaneous and orthotopic pancreatic cancer models.
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